sdf1 α Search Results


sdf1α  (Allen Institute for Brain Science)
90
Allen Institute for Brain Science sdf1α
( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , <t>SDF1α</t> , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004
Sdf1α, supplied by Allen Institute for Brain Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sdf1+%CE%B1/pmc05271606-201-1-18?v=Allen+Institute+for+Brain+Science
Average 90 stars, based on 1 article reviews
sdf1α - by Bioz Stars, 2026-08
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sdf-1 α  (NEN Life Science)
90
NEN Life Science sdf-1 α
( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , <t>SDF1α</t> , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004
Sdf 1 α, supplied by NEN Life Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sdf1+%CE%B1/pmc03019152-87-26-32?v=NEN+Life+Science
Average 90 stars, based on 1 article reviews
sdf-1 α - by Bioz Stars, 2026-08
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sdf1-α  (Perotech Sciences Inc)
90
Perotech Sciences Inc sdf1-α
( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , <t>SDF1α</t> , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004
Sdf1 α, supplied by Perotech Sciences Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sdf1+%CE%B1/pm38105187-112-15-21?v=Perotech+Sciences+Inc
Average 90 stars, based on 1 article reviews
sdf1-α - by Bioz Stars, 2026-08
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cbd-sdf1α  (Verlag GmbH)
90
Verlag GmbH cbd-sdf1α
( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , <t>SDF1α</t> , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004
Cbd Sdf1α, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sdf1+%CE%B1/pm27442189-95-27-14?v=Verlag+GmbH
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cdc-sourced sdf1α  (StemCells Inc)
90
StemCells Inc cdc-sourced sdf1α
( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , <t>SDF1α</t> , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004
Cdc Sourced Sdf1α, supplied by StemCells Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sdf1+%CE%B1/pm30171743-58-21-36?v=StemCells+Inc
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cdc-sourced sdf1α - by Bioz Stars, 2026-08
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nicht-sdf1α-beschichtetetransplantate  (Anwendung GmbH)
90
Anwendung GmbH nicht-sdf1α-beschichtetetransplantate
( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , <t>SDF1α</t> , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004
Nicht Sdf1α Beschichtetetransplantate, supplied by Anwendung GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sdf1+%CE%B1/10__1007_slash_s00398___020___00386___y-109-0-11?v=Anwendung+GmbH
Average 90 stars, based on 1 article reviews
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Image Search Results


( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , SDF1α , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004

Journal: eLife

Article Title: Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms

doi: 10.7554/eLife.20898

Figure Lengend Snippet: ( A ) Quantification of Lmx1a+ cells in the RL of WT and Foxc1 null mutants indicate that there is no difference in Lmx1a expression. p=0.17. Scale bar = 20 µm ( B ) Quantification of tdTomato+ cells present outside the EGL and RL area in WT and Foxc1 null mutants indicate that there is a significantly higher number of tdtomato+ cells present in the mutant, many of which are ectopic in nature. ***p<0.005 ( C ) Quantification of Ki67+ cells in the VZ of WT and Foxc1 hith/hith mutants indicate that there is no difference in proliferation. p=0.4. Scale bar = 100 µm ( D ) Mid-hindbrain expression of Foxc1 targets in e12.5 wild-type (black) and Foxc1 hith/hith (grey) littermate embryos, assayed by qRT-PCR. Foxc1 reduction decreases hindbrain mesenchyme expressed genes ( Tgfb1 , SDF1α , Bmp2 and Bmp4 ), but not neural tube expressed genes ( Fgf15 and Cxcr4 ). *p<0.05 , ** p<0.0001 . DOI: http://dx.doi.org/10.7554/eLife.20898.004

Article Snippet: Since SDF1α is expressed in the mouse posterior fossa mesenchyme prior to e12.5 ([ ], Website: © 2015 Allen Institute for Brain Science.

Techniques: Expressing, Mutagenesis, Quantitative RT-PCR

( A ) Schematic of a paramedial sagittal section of the embryonic mouse cerebellum. In the wild-type cerebellum, mesenchymal Foxc1 controls the expression of chemokine SDF1α which binds to its receptor Cxcr4 which is strongly expressed in the RL, EGL, and VZ. SDF1α functions as a chemoattractant to Lmx1a+ (red) and Lmx1a- (blue) GCPs exiting the RL to form the EGL, ensuring that these progenitors exit the RL and remain confined to the EGL underneath the pial surface. SDF1α also controls the migration of cells out of the VZ, acting as a chemoattractant. It is also required for the maintenance of radial glial fibers, which act as scaffolds for this migration. ( B ) In the Foxc1 -/- and Foxc1 hith/hith mice, deletion of Foxc1 leads to a significant downregulation of mesenchymal SDF1α by e12.5. This reduction results in excessive retention of posterior-fated cells in the RL and ectopic migration of cells out of the RL (red arrows) and precocious migration of GCPs from the EGL into the cerebellar anlage (blue arrows). Proliferation, migration, and VZ-derived neurons and radial glia are also negatively affected. DOI: http://dx.doi.org/10.7554/eLife.20898.010

Journal: eLife

Article Title: Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms

doi: 10.7554/eLife.20898

Figure Lengend Snippet: ( A ) Schematic of a paramedial sagittal section of the embryonic mouse cerebellum. In the wild-type cerebellum, mesenchymal Foxc1 controls the expression of chemokine SDF1α which binds to its receptor Cxcr4 which is strongly expressed in the RL, EGL, and VZ. SDF1α functions as a chemoattractant to Lmx1a+ (red) and Lmx1a- (blue) GCPs exiting the RL to form the EGL, ensuring that these progenitors exit the RL and remain confined to the EGL underneath the pial surface. SDF1α also controls the migration of cells out of the VZ, acting as a chemoattractant. It is also required for the maintenance of radial glial fibers, which act as scaffolds for this migration. ( B ) In the Foxc1 -/- and Foxc1 hith/hith mice, deletion of Foxc1 leads to a significant downregulation of mesenchymal SDF1α by e12.5. This reduction results in excessive retention of posterior-fated cells in the RL and ectopic migration of cells out of the RL (red arrows) and precocious migration of GCPs from the EGL into the cerebellar anlage (blue arrows). Proliferation, migration, and VZ-derived neurons and radial glia are also negatively affected. DOI: http://dx.doi.org/10.7554/eLife.20898.010

Article Snippet: Since SDF1α is expressed in the mouse posterior fossa mesenchyme prior to e12.5 ([ ], Website: © 2015 Allen Institute for Brain Science.

Techniques: Expressing, Migration, Derivative Assay